VANCOCTION VANILLOIDS: Vanillins in Mane&Glory and Rose Vanelle
Let’s take a closer look at how vanilloids help the body reset and regulate itself back to health.
Vancoction’s Pain Free Stuff (Mane&Glory) and Rose Vanelle both contain vanilloids.
Seen here is the Vanillin molecule, a vanilloid. It is a naturally occurring, organic compound in both Rose Vanelle and our Pain Free Stuff (Mane&Glory)
The Vanillin molecule is a type of vanilloid that is biosynthesized most notably by the orchid plant Vanilla planifolia. In a complex pathway called the phenylpropanoid pathway, the plant produces vanillin from the amino acids phenylalanine and tyrosine (1). Vanilloids in general are organic compounds that possess a vanillyl group - but they all resemble the molecule pictured above, with varying sizes.
We all know and love that distinct vanilla aroma, all thanks to vanillin… but Vancoction is thoroughly interested in Vanillin for its vastly unique effects upon the body. Studies show that vanilloids, with regular use, tell toxic cells to return to normal reproduction of cells. These toxic cells need to go: they’re dysfunctional in nature, with shortened DNA, and no longer following their full genetic script. Think of a repetitive stress injury - where over the years toxic cellular activity has become habitual and the body has essentially misbehaved itself into inflammation or even cancer.
This behavior may have been a way for the body to protect itself, but the trauma continues ad infinitum. For example, swelling as a result of injury can be good, because it can limit use of that area until it begins recovery; but when the habit becomes a PTSD habit, it can become an addictive behavior. Think of a sprain, where the sprained cells, tendons, ligaments and vessels just don't recover. They can be sitting around waiting for the body to make the same mistake. "We need to be swollen, because Albert always sprains his left ankle. We need to be ready for when it happens again!!"
This is where vanilloids come to the rescue - to train the traumatized tissues back into healthier behaviors. Vanilloids bring in new staff (new cells of the body) that aren’t following the bad habits of the long time workers.
Vanillin is a simple molecule with complex roles like all vanilloids. The vanilloids in pine tar, for example, exert similar effects on the body.
When the vanillin in Vancoction appears through absorption, it says “sayonara” to the toxic cells via apoptosis (cellular death). Vanilloids bind to a variety of receptors, proteins and membrane channels, exerting an array of effects - some show promise as cancer treatment, others as a remedy for pain and inflammation (2).
Vanilloids bind to a specific receptor called TRPV1 (transient receptor potential vanilloid 1 channel) or just vanilloid receptor 1. Fundamentally, this receptor is a protective mechanism, warning the body of dangerous heat by causing pain.
A graphic demonstrating that Vanillin, a Vanilloid, binds to an ion channel as an agonist